Bacteriophage Therapy: Exploiting Smaller Fleas
نویسندگان
چکیده
منابع مشابه
Bacteriophage therapy: exploiting smaller fleas.
Although bacteriophages have been used for the treatment of patients with bacterial infections in some regions of the world for >9 decades, adequate clinical trials of the safety and efficacy of the treatment have not been reported. The increasing problem of antibiotic resistance has, however, rekindled interest in this approach to therapy. Although potentially significant obstacles to systemic...
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Life forms can be roughly differentiated into those that are microscopic versus those that are not as well as those that are multicellular and those that, instead, are unicellular. Cellular organisms seem generally able to host viruses, and this propensity carries over to those that are both microscopic and less than truly multicellular. These viruses of microorganisms, or VoMs, in fact exist a...
متن کاملBacteriophage therapy.
The emergence of pathogenic bacteria resistant to most, if not all, currently available antimicrobial agents has become a critical problem in modern medicine, particularly because of the concomitant increase in immunosuppressed patients. The concern that humankind is reentering the “preantibiotics” era has become very real, and the development of alternative antiinfection modalities has become ...
متن کاملBacteriophage therapy.
In 1917, bacteriophages were recognized as epizootic infections of bacteria and were almost immediately deployed for antibacterial therapy and prophylaxis. The early trials of bacteriophage therapy for infectious diseases were confounded, however, because the biological nature of bacteriophage was poorly understood. The early literature reviewed here indicates that there are good reasons to bel...
متن کاملBacteriophage therapy of Salmonella enterica: a fresh appraisal of bacteriophage therapy.
BACKGROUND The most serious criticisms leveled at bacteriophage therapy are as follows: phages induce neutralizing antibodies, phages are active only when administered shortly after bacterial infection, and phage-resistant bacteria emerge rapidly in the course of therapy. METHODS Phages lytic for several Salmonella enterica serovars were isolated by means of standard protocols from feces of p...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2009
ISSN: 1058-4838,1537-6591
DOI: 10.1086/597405